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November 14th - According to sources familiar with the matter, Boeing is poised to win a major order for most of Dubai Airways single-aisle aircraft, although Airbus still has a slim chance of securing some business from the airline, which has never ordered aircraft from European manufacturers. The sources said both manufacturers are vying for the order of 200 narrow-body aircraft, with an option to purchase an additional 100. They indicated the deal could be announced at the Dubai Airshow, which begins on Monday. The sources stated the deal is not yet finalized. The state-owned airline may split the order or decide to opt for Boeing again. Dubai Airways currently uses only aircraft from the American company, but delays in receiving its 737 narrow-body aircraft have forced the airline to consider other options. The sources said Dubai Airways CEO Ghaith Al Ghaith visited Airbuss headquarters in Toulouse, France, a few weeks ago and discussed the size and price of potential purchases with executives. The sources said the airline had previously engaged in in-depth discussions with Airbus but ultimately withdrew. If a formal agreement is reached this time, it will mark the first time in its 17-year history that it has switched from Boeing to another manufacturer.Atlanta Fed President Bostic, a 2027 FOMC voting member, will speak in ten minutes.Swiss government: US tariffs will be reduced to 15%.On November 14th, Morgan Stanley analyst Bruna S. Karica stated in a report that the UK governments potential reversal of its plan to raise income taxes has reduced the likelihood of a Bank of England rate cut. Following reports on Friday suggesting the government would not raise income taxes, Skarica said Morgan Stanley is less certain about the size of funds available for anti-inflation measures, and more broadly, the size of pre-emptive fiscal austerity measures. Refinitiv data shows that market pricing in a December rate cut by the Bank of England has fallen from 81% on Thursday to 78%.U.S. Trade Representative Greer: The food tariff exclusion list will apply to countries that have reached an agreement with or have not reached an agreement with the United States.

Roche Discontinues The Majority of Alzheimer's Drug Trials Due to Failure

Aria Thomas

Dec 01, 2022 11:02

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The bulk of clinical trials of Roche's experimental Alzheimer's drug gantenerumab have been terminated, the company reported on Wednesday, after it failed to reduce the disease's progression in two large, late-stage testing.


Roche released the complete results of its twin studies at a symposium on Alzheimer's in San Francisco, after announcing in November that the drug had failed in both trials.


Roche's drug did not demonstrate a statistically significant benefit in patients with mild cognitive impairment and early Alzheimer's disease, in contrast to Eisai Co (OTC:ESALY) Ltd and Biogen Inc (NASDAQ:BIIBlecanemab,drug, )'s which is on track for U.S. regulatory approval after presenting positive trial results on Tuesday.


Both drugs are designed to eradicate beta amyloid types from the brain, which are believed to play a major part in the disease.


Compared to a placebo, Eisai's infusion delayed the advancement of Alzheimer's by 27% after 18 months, but Roche's drug showed just an 8% drop in the Graduate I study and a 6% decline in the Graduate II study after two years.


The drug's ability to eliminate amyloid from the brain may have been a distinctive feature.


Researchers noted in a presentation on Wednesday that gantenerumab, which is provided through injection, eliminated amyloid in just 28% of patients in the Graduate I trial and 25% of patients in the Graduate II study, which was half of what the firm had predicted.


Lecanemab eradicated amyloid in 68% of study subjects after 18 months.


Dr. Howard Fillit, chief science officer at the Alzheimer's Medicine Discovery (NASDAQ:WBD) Foundation, indicated that modifications in chemistry, dose, and administration by injection as opposed to infusion may have contributed to the failure of Roche's medicine.


The fact that the medication did not eradicate amyloid deposits in the brain as predicted had a substantial impact, he stated.


The field of Alzheimer's research is plagued by failure and disappointment, most notably for other drugs in the same class and previous attempts to demonstrate gantenerumab's effectiveness.


The drug failed to demonstrate a benefit when delivered at a decreased dose to individuals with moderate Alzheimer's in 2014, and it failed again in 2020 in a trial done by the Washington University School of Medicine on patients with an inherited type of Alzheimer's.


Clearly, certain drugs within the class are effective while others are ineffective, Fillet said.


According to an email statement from a company spokesman, Roche will cease all gantenerumab studies in early Alzheimer's disease, including extension studies of the Graduate trials and the Skyline Phase III investigation in patients with evidence of amyloid in the brain but no signs of cognitive decline.


"The amyloid clearance rate was lower than anticipated in graduate studies. We foresee a comparable, if less, effect on the Skyline population and think this insufficient for continuing "The representative stated.


In an effort to deliver more of the treatment to the brain, Roche continues to investigate trontinemab, an alternative formulation of gantenerumab designed to transport the medication across the blood brain barrier - protective blood vessels that prevent substances in the bloodstream from entering the brain.


Rachelle Doody, the global head of neurological drug development at Roche, said in a statement, "We remain committed to Alzheimer's disease and will move our focus to new and maybe improved ways for developing new treatments."

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